By Taotao Zou
This thesis specializes in the improvement of gold- and non-classical platinum-based anti-cancer brokers that demonstrate distinctively assorted anti-cancer mechanisms in comparison to the widely used cisplatin. those steel complexes include N-heterocyclic carbene (NHC) ligands that are in a position to shape powerful M-C(NHC) bonds, conferring excessive balance and favorable lipophilicity, reactivity and binding specificity of steel complexes on biomolecules. the writer demonstrates major advances made in anti-cancer gold(III), gold(I) and platinum(II) complexes. special chemical synthesis, in vitro and/or in vivo anti-cancer actions are basically provided together with: (i) a category of Au(III) complexes containing a hugely fluorescent N^N^N ligand and NHC ligand that concurrently act as fluorescent thiol “switch-on” probes and anti-cancer brokers; (ii) a dinuclear gold(I) complicated with a combined diphosphine and bis(NHC) ligand exhibiting favorable balance and exhibiting major inhibition of tumor progress in self sustaining mice types without observable unwanted effects; and (iii) a panel of reliable luminescent cyclometalated platinum(II) complexes displaying excessive specificity to localize to the endoplasmic reticulum (ER) area, inducing ER rigidity and mobile apoptosis. those works spotlight the scientific power that gold and platinum complexes provide for melanoma treatment.
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Extra info for Anti-Cancer N-Heterocyclic Carbene Complexes of Gold(III), Gold(I) and Platinum(II): Thiol “Switch-on” Fluorescent Probes, Thioredoxin Reductase Inhibitors ... Reticulum Targeting Agents (Springer Theses)
Anti-Cancer N-Heterocyclic Carbene Complexes of Gold(III), Gold(I) and Platinum(II): Thiol “Switch-on” Fluorescent Probes, Thioredoxin Reductase Inhibitors ... Reticulum Targeting Agents (Springer Theses) by Taotao Zou